When a liver transplant became the only curative option for my mother’s advanced Primary Biliary Cholangitis (PBC), I volunteered to become her living liver donor in January 2023. However, on March 29, she passed away from multiple complications—sepsis and acute respiratory distress syndrome. This concept is rooted in that heartbreaking time, shaped by one lingering question: what if there had been a targeted treatment that could have cured her disease?